Drug Interaction between Cefuroxime and Aluminum hydroxide

Cefuroxime is a semisynthetic cephalosporin antibiotic used in the treatment of bacterial infections as it acts by inhibiting microbial cell wall formation.
Aluminum hydroxide is often used along with other agents as an antacid used in management of heartburn, acid indigestion, peptic ulcer, gastritis, esophagitis, etc.

The concomitant use of both Cefuroxime and Aluminum hydroxide can lead to a major drug interaction. This is because Aluminum hydroxide, as an antacid, increases gastric pH (making the stomach more alkaline), which would decrease the pH-dependent drug dissolution and absorption of Cefuroxime. Studies have revealed that there is a reduction in Cmax and AUC of Cefuroxime by over 40%.
Generally, H2-receptor antagonists, proton pump inhibitors and antacids should be avoided with such antibiotics.

This is considered a major drug interaction in which an alternative is strongly advised.

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