Drug Interaction between Carbamazepine and Tramadol

Carbamazepine is an anti-convulsant that decreases nerve impulse transmission. Hence, it is used for the management of partial, tonic-clonic, mixed seizures. It is also used for the management of certain types of nerve pains like trigeminal neuralgia and glossopharyngeal neuralgia.
Tramadol is an opioid analgesic used to manage moderate to severe pain.

The concomitant use of both Carbamazepine and Tramadol can lead to a moderate drug interaction. This is because Carbamazepine induces the metabolism of Tramadol through CYP450 metabolic induction thereby reducing the analgesic effect of Tramadol.

This is considered a moderate drug interaction in which close monitoring is strongly advised.

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